BMS 536924 | Tocris Bioscience 4774 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BMS 536924

catalog :

4774

quantity :

10 mg (also 50 mg)

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Uchikawa E, Choi E, Shang G, Yu H, Bai X. Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. elife. 2019;8: pubmed publisher
Demian W, Persaud A, Jiang C, Coyaud E, Liu S, Kapus A, et al. The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1. Cell Rep. 2019;27:1886-1896.e6 pubmed publisher
Choi E, Kikuchi S, Gao H, Brodzik K, Nassour I, Yopp A, et al. Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling. Nat Commun. 2019;10:1473 pubmed publisher
Augustin H, McGourty K, Allen M, Adcott J, Wong C, Boucrot E, et al. Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiol Aging. 2018;66:149-157 pubmed publisher
Augustin H, McGourty K, Allen M, Madem S, Adcott J, Kerr F, et al. Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies. PLoS Biol. 2017;15:e2001655 pubmed publisher
Chinchore Y, Begaj T, Wu D, DROKHLYANSKY E, Cepko C. Glycolytic reliance promotes anabolism in photoreceptors. elife. 2017;6: pubmed publisher
Ising C, Koehler S, BrÃ¤hler S, Merkwirth C, HÃ¶hne M, Baris O, et al. Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med. 2015;7:275-87 pubmed publisher

product information

brand :

Tocris

master code :

4774

SKU :

4774/10

product name :

BMS 536924

description :

Dual IR/IGF1R inhibitor

target :

Insulin and Insulin-like Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

479.96

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dual inhibitor of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) (IC50 values are 73 and 100 nM respectively). Inhibits receptor autophosphorylation and downstream MEK1/2 and Akt signaling. Induces G1 arrest and apoptosis in ML-1 cells; also inhibits cell proliferation in multiple tumor types. Reverses EMT through the attenuation of Snail mRNA expression in MCF10A cell over expressing IGF1R.

catalog number base :

4774

product keywords :

BMS536924 antitumor antiproliferatives insulin receptor IR insulin-like growth factor-1 receptor IGF1R dual inhibitors inhibits EMT epithelial-to-mesenchymal transition Insulin and insulin-like Receptors Insulin and Insulin-like Receptors 4774,

extended description :

Dual IR/IGF1R inhibitor

chemical name text :

4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone

formula :

C 25 H 26 ClN 5 O 3

formula text :

C25H26ClN5O3

cas num :

468740-43-4

2020 USD :

280

2021 USD :

292 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage