ESI 09 | Tocris Bioscience 4773/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ESI 09

catalog :

4773/10

quantity :

10 mg (also 50 mg)

price :

246 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Lim Y, Cho I, Rennke H, Cho G. β2-adrenergic receptor regulates ER-mitochondria contacts. Sci Rep. 2021;11:21477 pubmed publisher
Goode D, Molliver D. Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci. 2021;41:2883-2898 pubmed publisher
Cuddy S, Schinlever A, Dochnal S, Seegren P, Suzich J, Kundu P, et al. Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. elife. 2020;9: pubmed publisher
Kaplan A, Andrei S, van Regteren Altena A, Simas T, Banerjee S, Kato N, et al. Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol. 2020;27:657-667.e6 pubmed publisher
Hilgendorf K, Johnson C, Mezger A, Rice S, Norris A, Demeter J, et al. Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell. 2019;179:1289-1305.e21 pubmed publisher
Kayhan M, Koyas A, Akdemir I, Savas A, Cekic C. Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype. J Immunol. 2019;203:3247-3255 pubmed publisher
Sunilkumar S, Ford S. Elevated glucose concentration in culture media decreases membrane trafficking of SGLT2 in LLC-PK1 cells via a cAMP/PKA-dependent pathway. Am J Physiol Cell Physiol. 2019;316:C913-C924 pubmed publisher
Goode D, Molliver D. Phospho-substrate profiling of Epac-dependent protein kinase C activity. Mol Cell Biochem. 2019;456:167-178 pubmed publisher
Perkins D, Richard K, Hansen A, Lai W, Nallar S, Koller B, et al. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat Immunol. 2018;19:1309-1318 pubmed publisher
Drelich A, Judy B, He X, Chang Q, Yu S, Li X, et al. Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells. Viruses. 2018;10: pubmed publisher
Ramos C, Lin C, Liu X, Antonetti D. The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. J Biol Chem. 2018;293:717-730 pubmed publisher
Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, et al. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog. 2017;13:e1006603 pubmed publisher
Wang J, Cao Y, Li Q, Yang Y, Jin M, Chen D, et al. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy. 2015;11:2057-2073 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4773

SKU :

4773/10

product name :

ESI 09

description :

Epac inhibitor

target :

EPAC Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

330.77

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ESI 09 is an EPAC inhibitor. Inhibits EPAC-mediated insulin release from pancreatic cells. Selective for EPAC over PKA. ESI 09 decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro .

product keywords :

ESI09 EPAC exchange proteins inhibitors inhibits GTPases Rap guanine nucleotide exchange factor cAMP GEFI EPAC 4773,

extended description :

Epac inhibitor

chemical name text :

-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)- -oxo-3-isoxazolepropanenitrile

formula :

C16H15ClN4O2

formula text :

C16H15ClN4O2

cas num :

263707-16-0

USD :

243

USD 2025 :

246 USD

product details :

Epac inhibitor

more info or order :

Tocris Bioscience product webpage