4763/10 | Tocris Bioscience 4763/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4763/10

catalog :

4763/10

quantity :

10 mg

price :

292 USD

citations: 1

Reference
Hagen T, Laski A, Br xfc mmer A, Pru x161 ka A, Schl xf6 sser V, Cl xe9 ry A, et al. Inosine Substitutions in RNA Activate Latent G-Quadruplexes. J Am Chem Soc. 2021;143:15120-15130 pubmed publisher

product information

master code :

4763

SKU :

4763/10

product name :

Pyridostatin pentahydrochloride

unit size :

10 mg

description :

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

target :

Cell Cycle Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

778.94

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).

top caption :

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

extended description :

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

chemical name text :

4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride

formula :

C31H32N8O5.5HCl

formula text :

C31H32N8O5.5HCl

cas num :

1781882-65-2

USD :

292 USD

product details :

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

storage :

Desiccate at RT