MIM1 | Tocris Bioscience 4762 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MIM1

catalog :

4762

quantity :

10 mg (also 50 mg)

price :

162 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Li H, Li Y, Morin D, Plymate S, Lye S, Dong X. The androgen receptor mediates antiapoptotic function in myometrial cells. Cell Death Dis. 2014;5:e1338 pubmed publisher

product information

brand :

Tocris

master code :

4762

SKU :

4762/10

product name :

MIM1

description :

Mcl-1 inhibitor; proapoptotic

target :

Bcl-2 Family Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

347.43

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of Mcl-1. Inhibits Mcl-1 indirectly by induction of the proapoptotic Mcl-1 ligand NOXA via the unfolded protein response (UPR) pathway. Sensitizes leukemia cells to the Bcl-2 inhibitor venetoclax (ABT-199). Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro .

catalog number base :

4762

product keywords :

Mcl-1 inhibitors inhibits proapoptotic induces apoptosis caspases activation induces NOXA Bcl-2 Family 4762,

extended description :

Mcl-1 inhibitor; proapoptotic

chemical name text :

4-(E)-[[(2Z)-2-cyclohexylimino)-4-methyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1,2,3-triol

formula :

C 17 H 21 N 3 O 3 S

formula text :

C17H21N3O3S

2020 USD :

179

2021 USD :

162 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage