Plumbagin | Tocris Bioscience 4761/50 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Plumbagin

catalog :

4761/50

quantity :

50 mg

price :

49 USD

product information

brand :

Tocris

MasterCode :

4761

SKU :

4761/50

product name :

Plumbagin

unit sizes :

50 mg

description :

Induces G2/M cell cycle arrest; anticancer

target :

Cell Cycle Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

188.18

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Plumbagin is an anticancer agent. Induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation; inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Induces intracellular ROS generation in a PI 5-kinase-dependent manner. Also inhibits p300-mediated acetylation of p53.

extended description :

Induces G2/M cell cycle arrest; anticancer

chemical name text :

5-Hydroxy-2-methyl-1,4-naphthalenedione

formula :

C 11 H 8 O 3

formula text :

C11H8O3

cas num :

481-42-5

USD :

49 USD

product details :

Induces G2/M cell cycle arrest; anticancer

storage :

Store at -20°C