G-36 | Tocris Bioscience 4759/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

G-36

catalog :

4759/10

quantity :

10 mg

price :

267 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Xu J, Bai J, Gao F, Xu C, Huang Y, Li D, et al. Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats. Biology (Basel). 2023;12: pubmed publisher
Bai N, Zhang Q, Zhang W, Liu B, Yang F, Brann D, et al. G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense. J Neuroinflammation. 2020;17:45 pubmed publisher
Meseke M, Neumüller F, Brunne B, Li X, Anstötz M, Pohlkamp T, et al. Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin. Eneuro. 2018;5: pubmed publisher

image

image 1 :

Cat.No. 4759 - G-36 C22H22BrNO2 CAS No. 1392487-51-2

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4759

SKU :

4759/10

product name :

G-36

description :

Selective GPER antagonist

target :

Estrogen and Related Receptor Antagonists

unit size :

10 mg

category :

Small Molecules

purity :

99%

storage :

Store at -20°C

observed molecular weight :

412.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

G-36 is an antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ER . Also inhibits estrogen-mediated calcium mobilization (IC50 = 112 nM). Structural analog of G-1 (Cat. No. 3577).

product keywords :

G36 G-protein-coupled estrogen receptors GPER GPR30 antagonists selective Estrogen (GPER) Receptors 4759,

extended description :

Selective GPER antagonist

chemical name text :

( )-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline

formula :

C22H22BrNO2

formula text :

C22H22BrNO2

cas num :

1392487-51-2

USD :

264

USD 2025 :

267 USD

product details :

Selective GPER antagonist

more info or order :

Tocris Bioscience product webpage