ML 221 | Tocris Bioscience 4748 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 221

catalog :

4748

quantity :

10 mg (also 50 mg)

price :

223 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Yang P, Read C, Kuc R, Buonincontri G, Southwood M, Torella R, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017;135:1160-1173 pubmed publisher
Hall C, Ehrlich L, Venter J, O Brien A, White T, Zhou T, et al. Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Lett. 2017;386:179-188 pubmed publisher

product information

brand :

Tocris

master code :

4748

SKU :

4748/10

product name :

ML 221

description :

Apelin antagonist

target :

Apelin Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

385.35

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Apelin receptor (APJ) antagonist (IC50 values are 0.70 and 1.75 M in a cAMP assay and -arrestin assay, respectively). Displays 37-fold selectivity over the closely related angiotensin II type 1 (AT1) receptor. Exhibits no toxicity towards human hepatocytes at concentrations 50 M.

catalog number base :

4748

product keywords :

ML221 apelin receptors APJ antagonists Apelin Receptors 4748,

extended description :

Apelin antagonist

chemical name text :

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one

formula :

C 17 H 11 N 3 O 6 S

formula text :

C17H11N3O6S

cas num :

877636-42-5

2020 USD :

214

2021 USD :

223 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage