ML 221 | Tocris Bioscience 4748/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 221

catalog :

4748/10

quantity :

10 mg (also 50 mg)

price :

259 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Yang P, Read C, Kuc R, Buonincontri G, Southwood M, Torella R, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017;135:1160-1173 pubmed publisher
Hall C, Ehrlich L, Venter J, O Brien A, White T, Zhou T, et al. Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Lett. 2017;386:179-188 pubmed publisher

product information

brand :

Tocris

master code :

4748

SKU :

4748/10

rank :

0.061

product name :

ML 221

description :

Apelin antagonist

target :

Apelin Receptor Antagonists

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML 221 is an apelin receptor (APJ) antagonist (IC50 values are 0.70 and 1.75 M in a cAMP assay and -arrestin assay, respectively). Displays 37-fold selectivity over the closely related angiotensin II type 1 (AT1) receptor. Exhibits no toxicity towards human hepatocytes at concentrations 50 M.

extended description :

Apelin antagonist

chemical name text :

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one

formula :

C 17 H 11 N 3 O 6 S

formula text :

C17H11N3O6S

cas num :

877636-42-5

USD :

259 USD

product details :

Apelin antagonist

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage