product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
ML 221
catalog :
4748/10
quantity :
10 mg (also 50 mg)
price :
281 USD
more info or order :
citations: 3
Reference
Mlyczy x144 ska E, Myszka M, Kurowska P, Dawid M, Milewicz T, Ba x142 ajewicz Nowak M, et al. Anti-Apoptotic Effect of Apelin in Human Placenta: Studies on BeWo Cells and Villous Explants from Third-Trimester Human Pregnancy. Int J Mol Sci. 2021;22: pubmed publisher
Yang P, Read C, Kuc R, Buonincontri G, Southwood M, Torella R, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017;135:1160-1173 pubmed publisher
Hall C, Ehrlich L, Venter J, O Brien A, White T, Zhou T, et al. Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Lett. 2017;386:179-188 pubmed publisher
product information
brand :
Tocris
catalog number base :
4748
SKU :
4748/10
product name :
ML 221
units size :
10 mg (also 50 mg)
description :
Apelin antagonist
target :
Apelin Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
385.35
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ML 221 is an apelin receptor (APJ) antagonist (IC50 values are 0.70 and 1.75 M in a cAMP assay and -arrestin assay, respectively). Displays 37-fold selectivity over the closely related angiotensin II type 1 (AT1) receptor. Exhibits no toxicity towards human hepatocytes at concentrations 50 M.
top caption :
Apelin antagonist
extended description :
Apelin antagonist
chemical name text :
5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
formula :
C17H11N3O6S
formula text :
C17H11N3O6S
cas num :
877636-42-5
USD :
281 USD
product details :
Apelin antagonist
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK