ML SA1 | Tocris Bioscience 4746/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML SA1

catalog :

4746/10

quantity :

10 mg (also 50 mg)

price :

150 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Van Acker Z, Perdok A, Hellemans R, North K, Vorsters I, Cappel C, et al. Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism. Nat Commun. 2023;14:2847 pubmed publisher
Pineau J, Pinon L, Mesdjian O, Fattaccioli J, Lennon Dum xe9 nil A, Pierobon P. Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes. elife. 2022;11: pubmed publisher
Gu M, Hu M, Minckley T, Pinchi P, Xu H, Qin Y, et al. A protocol to measure lysosomal Zn2+ release through a genetically encoded Zn2+ indicator. STAR Protoc. 2022;3:101453 pubmed publisher
Sun J, Liu Y, Hao X, Lin W, Su W, Chiang E, et al. LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function. EMBO J. 2022;41:e108119 pubmed publisher
Smith S, Fabian L, Sheikh A, Noche R, Cui X, Moore S, et al. Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy. Hum Mol Genet. 2021;: pubmed publisher
Huang L, Li H, Ye Z, Xu Q, Fu Q, Sun W, et al. Berbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR). Emerg Microbes Infect. 2021;10:1257-1271 pubmed publisher
Edwards Jorquera S, Bosveld F, Bella xef che Y, Lennon Dum xe9 nil A, Glavic x. Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages. J Cell Biol. 2020;219: pubmed publisher
Fine M, Schmiege P, Li X. Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun. 2018;9:4192 pubmed publisher

image

image 1 :

Cat.No. 4746 - ML SA1 C22H22N2O3 CAS No. 332382-54-4

product information

brand :

Tocris

MasterCode :

4746

SKU :

4746/10

product name :

ML SA1

target :

TRPML Channel Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

362.42

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.

extended description :

Activator of TRPML channels

chemical name text :

2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

formula :

C 22 H 22 N 2 O 3

formula text :

C22H22N2O3

cas num :

332382-54-4

USD :

150 USD

product details :

Activator of TRPML channels

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage