LIMKi 3 | Tocris Bioscience 4745 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LIMKi 3

catalog :

4745

quantity :

10 mg

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Georgouli M, Herraiz C, Crosas Molist E, Fanshawe B, Maiques O, Perdrix A, et al. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. Cell. 2019;176:757-774.e23 pubmed publisher
Sparrow N, Manetti M, Bott M, Fabianac T, Petrilli A, Bates M, et al. The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination. J Neurosci. 2012;32:5284-97 pubmed publisher

product information

brand :

Tocris

master code :

4745

SKU :

4745/10

product name :

LIMKi 3

description :

Potent LIM kinase inhibitor; antitumor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

431.29

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively). Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.

catalog number base :

4745

product keywords :

LIMKi3 potent lim kinases inhibitors inhibits antitumor BMS5 BMS 5 LIMK 4745,

extended description :

Potent LIM kinase inhibitor; antitumor

chemical name text :

N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide

formula :

C 17 H 14 Cl 2 F 2 N 4 OS

cas num :

1338247-35-0

2020 USD :

218

2021 USD :

227 USD

alt names :

BMS 5

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage