LIMKi 3 | Tocris Bioscience 4745/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LIMKi 3

catalog :

4745/10

quantity :

10 mg

price :

286 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Bolger Munro M, Choi K, Cheung F, Liu Y, Dang Lawson M, Deretic N, et al. The Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse. Front Cell Dev Biol. 2021;9:649433 pubmed publisher
Mamula D, Korthals M, Hradsky J, Gottfried A, Fischer K, Tedford K. Arhgef6 (alpha-PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence. J Leukoc Biol. 2021;110:839-852 pubmed publisher
Burat B, Faucher Q, x10c echov xe1 P, Arnion H, Di Meo F, Sauvage F, et al. Cyclosporine A inhibits MRTF-SRF signaling through Na+/K+ ATPase inhibition and actin remodeling. FASEB Bioadv. 2019;1:561-578 pubmed publisher
Georgouli M, Herraiz C, Crosas Molist E, Fanshawe B, Maiques O, Perdrix A, et al. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. Cell. 2019;176:757-774.e23 pubmed publisher
Kemp J, Brieher W. The actin filament bundling protein α-actinin-4 actually suppresses actin stress fibers by permitting actin turnover. J Biol Chem. 2018;293:14520-14533 pubmed publisher
Sparrow N, Manetti M, Bott M, Fabianac T, Petrilli A, Bates M, et al. The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination. J Neurosci. 2012;32:5284-97 pubmed publisher

product information

brand :

Tocris

catalog number base :

4745

SKU :

4745/10

product name :

LIMKi 3

units size :

10 mg

description :

Potent LIM kinase inhibitor; antitumor

target :

LIMK Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

431.29

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LIMKi 3 is a potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively). Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.

top caption :

Potent LIM kinase inhibitor; antitumor

extended description :

Potent LIM kinase inhibitor; antitumor

chemical name text :

N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide

formula :

C17H14Cl2F2N4OS

cas num :

1338247-35-0

USD :

286 USD

product details :

Potent LIM kinase inhibitor; antitumor

alt names :

BMS 5

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage