LY 333531 hydrochloride | Tocris Bioscience 4738 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LY 333531 hydrochloride

catalog :

4738

quantity :

1 mg

price :

179 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Cosgrove B, Mui K, Driscoll T, Caliari S, Mehta K, Assoian R, et al. N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells. Nat Mater. 2016;15:1297-1306 pubmed publisher
Ezell S, Wang S, Bihani T, Lai Z, Grosskurth S, Tepsuporn S, et al. Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse large B cell lymphoma. Oncotarget. 2016;7:9163-74 pubmed publisher
Muellner M, Mair B, Ibrahim Y, Kerzendorfer C, Lechtermann H, Trefzer C, et al. Targeting a cell state common to triple-negative breast cancers. Mol Syst Biol. 2015;11:789 pubmed publisher

product information

brand :

Tocris

master code :

4738

SKU :

4738/1

product name :

LY 333531 hydrochloride

description :

Protein kinase C inhibitor; selective for isozymes

target :

Protein Kinase C Inhibitors

category :

Small Molecules

unit size :

1 mg

observed molecular weight :

505.01

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKC I and PKC II (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKC over other PKC isozymes (IC50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and 100 M for PKC , - , - , - , - and - respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).

catalog number base :

4738

product keywords :

LY333531 hydrochloride Ruboxistaurin protein kinase c PKC PKCb isozymes selective PKCBI PKCbetaI PKC I PKCBII PKCbetaII PKC II PKCB1 PKCbeta1 PKC 1 PKCB2 PKCbeta2 PKC 2 inhbitors inhibits Ruboxistaurin Protein Kinase C 4738,

extended description :

Protein kinase C inhibitor; selective for isozymes

chemical name text :

(9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride

formula :

C 28 H 28 N 4 O 3 .HCl

formula text :

C28H28N4O3.HCl

cas num :

169939-93-9

2020 USD :

175

2021 USD :

179 USD

alt names :

Ruboxistaurin

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage