product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
CDDO Im
catalog :
4737/10
quantity :
10 mg
price :
298 USD
more info or order :
citations: 6
Reference
Rush B, Bondi C, Stocker S, Barry K, Small S, Ong J, et al. Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice. Kidney Int. 2021;99:102-116 pubmed publisher
Park P, Mun S, Zeng S, Kim H, Bae S, Park Min K. NRF2 Is an Upstream Regulator of MYC-Mediated Osteoclastogenesis and Pathological Bone Erosion. Cells. 2020;9: pubmed publisher
Nagashima R, Kosai H, Masuo M, Izumiyama K, Noshikawaji T, Morimoto M, et al. Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response. J Immunol. 2019;202:1331-1339 pubmed publisher
Hiebert P, WIETECHA M, Cangkrama M, Haertel E, Mavrogonatou E, Stumpe M, et al. Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome. Dev Cell. 2018;46:145-161.e10 pubmed publisher
Kikuchi K, Iida M, Ikeda N, Moriyama S, Hamada M, Takahashi S, et al. Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation. J Immunol. 2018;201:635-651 pubmed publisher
Chartoumpekis D, Palliyaguru D, Wakabayashi N, Fazzari M, Khoo N, Schopfer F, et al. Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2018;315:E180-E195 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
4737
SKU :
4737/10
product name :
CDDO Im
description :
Nrf2 signaling activator
target :
Nrf2 Activators
unit size :
10 mg
category :
Small Molecules
purity :
98%
storage :
Store at RT
observed molecular weight :
541.72
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CDDO Im is an Nrf2 signaling activator; increases Nrf2 protein expression and enhances Nrf2-dependent cytoprotective gene expression. CDDO Im inhibits cell growth and induces apoptosis of pancreatic cancer cells in vitro . Also reduces acetaminophen -induced liver injury in mice.
product keywords :
CDDOIm Nrf2 activators NFE2L2 erythroid-derived nuclear factor Nrf2 4737,
extended description :
Nrf2 signaling activator
chemical name text :
1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole
formula :
C34H43N3O3
cas num :
443104-02-7
USD :
295
USD 2025 :
298 USD
product details :
Nrf2 signaling activator
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK