KY 02111 | Tocris Bioscience 4731/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

KY 02111

catalog :

4731/5

quantity :

5 mg (also 25 mg)

price :

108 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Bhagwan J, Collins E, Mosqueira D, Bakar M, Johnson B, Thompson A, et al. Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour. F1000Res. 2019;8:1911 pubmed publisher
Smith J, Owen T, Bhagwan J, Mosqueira D, Scott E, Mannhardt I, et al. Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits. Stem Cell Reports. 2018;11:1226-1243 pubmed publisher
Qiu X, Liu Y, Zhang Y, Guan Y, Jia Q, Wang C, et al. Rapamycin and CHIR99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53-Dependent Apoptosis. J Am Heart Assoc. 2017;6: pubmed publisher

image

image 1 :

Cat.No. 4731 - KY 02111 C18H17ClN2O3S CAS No. 1118807-13-8

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4731

SKU :

4731/5

product name :

KY 02111

description :

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

target :

Compounds for Stem Cell Differentiation

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

376.86

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

KY 02111 promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.

product keywords :

KY02111 stem cell differentiation cardiomyocytes human iPSCs ESCs Wnt signaling pathway inhibits inhibitors Other Wnt Signaling Cardiomyocyte Stem Cells ESCs and iPSC 4731, differentiation stem cells, DIFFERENTIATION STEM CELLS

extended description :

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

chemical name text :

N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide

formula :

C18H17ClN2O3S

formula text :

C18H17ClN2O3S

cas num :

1118807-13-8

USD :

103

USD 2025 :

108 USD

product details :

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

more info or order :

Tocris Bioscience product webpage