GS 6201 | Tocris Bioscience 4727/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GS 6201

catalog :

4727/10

quantity :

10 mg (also 50 mg)

price :

242 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Dai Q, Gao J, Xin J, Liu Q, Jing X, Yu X. The Role of Adenosine A2b Receptor in Mediating the Cardioprotection of Electroacupuncture Pretreatment via Influencing Ca2+ Key Regulators. Evid Based Complement Alternat Med. 2019;2019:6721286 pubmed publisher
Mertens T, Hanmandlu A, Tu L, Phan C, Collum S, Chen N, et al. Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension. Front Physiol. 2018;9:555 pubmed publisher
Perez Aso M, Montesinos M, Mediero A, Wilder T, Schafer P, Cronstein B. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015;17:249 pubmed publisher

product information

brand :

Tocris

catalog number base :

4727

SKU :

4727/10

product name :

GS 6201

units size :

10 mg (also 50 mg)

description :

Selective A2B antagonist

target :

Adenosine A2b Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

446.43

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GS 6201 is a selective antagonist of adenosine A2B receptors (Ki values are 22, 1070, 1940 and 3280 nM for human A2B, A3, A1 and A2A receptors respectively). Attenuates allergen-, NECA- and AMP-induced airway reactivity in an allergic mouse model of asthma. Also shown to attenuate the inflammatory response during acute myocardial infarction in mice; reduces caspase-1 activity in the heart.

top caption :

Selective A2B antagonist

extended description :

Selective A2B antagonist

chemical name text :

3-Ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-1H-purine-2,6-dione

formula :

C21H21F3N6O2

formula text :

C21H21F3N6O2

cas num :

752222-83-6

USD :

242 USD

product details :

Selective A2B antagonist

alt names :

CVT 6883

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage