T2AA | Tocris Bioscience 4723 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

T2AA

catalog :

4723

quantity :

10 mg (also 50 mg)

price :

158 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, Evison B, et al. Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012;287:14289-300 pubmed publisher

product information

brand :

Tocris

master code :

4723

SKU :

4723/10

product name :

T2AA

description :

PCNA inhibitor

target :

DNA, RNA and Protein Synthesis Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

511.09

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 M). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase and arrests cell growth in S-phase. Suppresses cancer cell growth.

catalog number base :

4723

product keywords :

Proliferating cell nuclear antigen PCNA inhibitors inhibits DNA replication forks DNA, RNA and Protein Synthesis DNA Polymerase 4723,

extended description :

PCNA inhibitor

chemical name text :

( S)- -Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol

formula :

C 15 H 15 I 2 NO 3

cas num :

1380782-27-3

2020 USD :

154

2021 USD :

158 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage