T2AA | Tocris Bioscience 4723/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

T2AA

catalog :

4723/10

quantity :

10 mg (also 50 mg)

price :

198 USD

citations: 2

Reference
Drosopoulos W, Vierra D, Kenworthy C, Coleman R, Schildkraut C. Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo. Cell Rep. 2020;30:1329-1341.e5 pubmed publisher
Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, Evison B, et al. Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012;287:14289-300 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4723

SKU :

4723/10

product name :

T2AA

description :

PCNA inhibitor

target :

DNA, RNA and Protein Synthesis Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

511.09

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 M). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase and arrests cell growth in S-phase. Suppresses cancer cell growth.

product keywords :

Proliferating cell nuclear antigen PCNA inhibitors inhibits DNA replication forks DNA, RNA and Protein Synthesis DNA Polymerase 4723,

extended description :

PCNA inhibitor

chemical name text :

( S)- -Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol

formula :

C15H15I2NO3

cas num :

1380782-27-3

USD :

196

USD 2025 :

198 USD

product details :

PCNA inhibitor