VU 0463271 | Tocris Bioscience 4719 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0463271

catalog :

4719

quantity :

10 mg (also 50 mg)

price :

196 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Alfonsa H, Lakey J, Lightowlers R, Trevelyan A. Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons. Nat Commun. 2016;7:13495 pubmed publisher
PÃ¡l I, Kardos J, Dobolyi Ã, HÃ©ja L. Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Mol Brain. 2015;8:35 pubmed publisher

product information

brand :

Tocris

master code :

4719

SKU :

4719/10

product name :

VU 0463271

description :

Potent and selective KCC2 inhibitor

target :

Other Ion Pump/Transporter Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

382.5

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 61 nM); displays 100-fold selectivity versus the Na-K-2Cl cotransporter 1 (NKCC1) and no activity against a panel of 68 GPCRs, ion channels and transporters.

catalog number base :

4719

product keywords :

VU0463271 potent selective inhibitors inhibits neuronal K-Cl cotransporters KCC2 K+/Cl- Cotransporter 2 4719, SLC 12A5, SLC12 A5, KCC 2, Solute Carrier Family 12 (Potassium/Chloride Transporters) Member 3, Potassium-chloride cotransporter, Neuronal K-Cl cotransporter, K-Cl symporter, Electroneutral potassium-chloride cotransporter 22

extended description :

Potent and selective KCC2 inhibitor

chemical name text :

N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

formula :

C 19 H 18 N 4 OS 2

cas num :

1391737-01-1

2020 USD :

188

2021 USD :

196 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage