Huwentoxin IV | Tocris Bioscience 4718/100U product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Huwentoxin IV

catalog :

4718/100U

quantity :

100 ug

price :

229 USD

citations: 1

Reference
Shen H, Liu D, Wu K, Lei J, Yan N. Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019;363:1303-1308 pubmed publisher

product information

brand :

Tocris

master code :

4718

SKU :

4718/100U

product name :

Huwentoxin IV

target :

Voltage-gated Sodium Channel Blockers

category :

Peptides

unit sizes :

100 ug

observed molecular weight :

4106.79

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Huwentoxin IV is a selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = 10 M). Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.

extended description :

Selective NaV1.7 channel blocker

formula :

C 174 H 278 N 52 O 51 S 6

formula text :

C174H278N52O51S6

cas num :

526224-73-7

USD :

229 USD

product details :

Selective NaV1.7 channel blocker

storage :

Store at -20°C