A 967079 | Tocris Bioscience 4716 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 967079

catalog :

4716

quantity :

10 mg (also 50 mg)

price :

162 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Zhao J, Lin King J, Paulsen C, Cheng Y, Julius D. Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature. 2020;585:141-145 pubmed publisher
Cheng R, Feng Y, Liu D, Wang Z, Zhang J, Chen L, et al. The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. Theranostics. 2019;9:4287-4307 pubmed publisher
Jiang L, Ma D, Grubb B, Wang M. ROS/TRPA1/CGRP signaling mediates cortical spreading depression. J Headache Pain. 2019;20:25 pubmed publisher
Ko M, Ganzen L, Coşkun E, Mukadam A, Leung Y, van Rijn R. A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep. 2019;9:2430 pubmed publisher
Wu S, Fowler D, Shaffer F, Lindberg J, Peters J. Ethyl Vanillin Activates TRPA1. J Pharmacol Exp Ther. 2017;362:368-377 pubmed publisher
Ganley R, Iwagaki N, Del Río P, Baseer N, Dickie A, Boyle K, et al. Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets. J Neurosci. 2015;35:7626-42 pubmed publisher
Paulsen C, Armache J, Gao Y, Cheng Y, Julius D. Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature. 2015;520:511-7 pubmed publisher

product information

brand :

Tocris

master code :

4716

SKU :

4716/10

product name :

A 967079

description :

Selective TRPA1 channel blocker

target :

TRPA1 Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

207.24

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively). Displays 1000-fold selectivity for TRPA1 over other TRP channels, and is 150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. Exhibits analgesic effects in a rat osteoarthritic pain model.

catalog number base :

4716

product keywords :

A967079 TRPA1 blockers selective TRP channels transient receptor potential TRPA1 4716,

extended description :

Selective TRPA1 channel blocker

chemical name text :

(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime

formula :

C 12 H 14 FNO

formula text :

C12H14FNO

cas num :

1170613-55-4

2020 USD :

155

2021 USD :

162 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage