A 967079 | Tocris Bioscience 4716/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 967079

catalog :

4716/10

quantity :

10 mg (also 50 mg)

price :

192 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Lowin T, Tigges Perez M, Constant E, Pongratz G. Anti-Inflammatory Effects of Cannabigerol in Rheumatoid Arthritis Synovial Fibroblasts and Peripheral Blood Mononuclear Cell Cultures Are Partly Mediated by TRPA1. Int J Mol Sci. 2023;24: pubmed publisher
Hu Y, Fu Q, Fu D, Wang X, Wang Z, Zhang J, et al. The Role of Transient Receptor Potential A1 and G Protein-Coupled Receptor 39 in Zinc-Mediated Acute and Chronic Itch in Mice. Front Mol Neurosci. 2021;14:768731 pubmed publisher
Kowalski C, Ragozzino F, Lindberg J, Peterson B, Lugo J, McLaughlin R, et al. Cannabidiol activation of vagal afferent neurons requires TRPA1. J Neurophysiol. 2020;124:1388-1398 pubmed publisher
Lowin T, Tingting R, Zurmahr J, Classen T, Schneider M, Pongratz G. Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts. Cell Death Dis. 2020;11:714 pubmed publisher
Zhao J, Lin King J, Paulsen C, Cheng Y, Julius D. Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature. 2020;585:141-145 pubmed publisher
Liu X, Wang D, Wen Y, Zeng L, Li Y, Tao T, et al. Spinal GRPR and NPRA Contribute to Chronic Itch in a Murine Model of Allergic Contact Dermatitis. J Invest Dermatol. 2020;140:1856-1866.e7 pubmed publisher
Cheng R, Feng Y, Liu D, Wang Z, Zhang J, Chen L, et al. The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. Theranostics. 2019;9:4287-4307 pubmed publisher
Jiang L, Ma D, Grubb B, Wang M. ROS/TRPA1/CGRP signaling mediates cortical spreading depression. J Headache Pain. 2019;20:25 pubmed publisher
Ko M, Ganzen L, Coşkun E, Mukadam A, Leung Y, van Rijn R. A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep. 2019;9:2430 pubmed publisher
Wu S, Fowler D, Shaffer F, Lindberg J, Peters J. Ethyl Vanillin Activates TRPA1. J Pharmacol Exp Ther. 2017;362:368-377 pubmed publisher
Ganley R, Iwagaki N, Del Río P, Baseer N, Dickie A, Boyle K, et al. Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets. J Neurosci. 2015;35:7626-42 pubmed publisher
Paulsen C, Armache J, Gao Y, Cheng Y, Julius D. Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature. 2015;520:511-7 pubmed publisher

image

image 1 :

Cat.No. 4716 - A 967079 C12H14FNO CAS No. 1170613-55-4

product information

brand :

Tocris

MasterCode :

4716

SKU :

4716/10

product name :

A 967079

target :

TRPA1 Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

207.24

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A 967079 (also known as A-079) is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively) that displays 1000-fold selectivity for TRPA1 over other TRP channels, and is 150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. A 967079 exhibits analgesic effects in a rat osteoarthritic pain model.

extended description :

Selective TRPA1 channel blocker

chemical name text :

(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime

formula :

C 12 H 14 FNO

formula text :

C12H14FNO

cas num :

1170613-55-4

USD :

192 USD

product details :

Selective TRPA1 channel blocker

alt names :

A-079

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage