IQ 1 | Tocris Bioscience 4713 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IQ 1

catalog :

4713

quantity :

10 mg (also 50 mg)

price :

189 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Koopmans T, Eilers R, Menzen M, Halayko A, Gosens R. ?-Catenin Directs Nuclear Factor-?B p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle. Front Immunol. 2017;8:1086 pubmed publisher
Koopmans T, Crutzen S, Menzen M, Halayko A, Hackett T, Knight D, et al. Selective targeting of CREB-binding protein/?-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle. Br J Pharmacol. 2016;173:3327-3341 pubmed publisher
Long K, Moss L, Laursen L, Boulter L, ffrench Constant C. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. Nat Commun. 2016;7:10354 pubmed publisher
Miyabayashi T, Teo J, Yamamoto M, McMillan M, Nguyen C, Kahn M. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A. 2007;104:5668-73 pubmed

product information

brand :

Tocris

master code :

4713

SKU :

4713/10

product name :

IQ 1

description :

Enables Wnt/ -catenin-driven expansion of ESCs; prevents spontaneous differentiation

target :

Compounds for Induced Pluripotent Stem Cells

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

362.42

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/ -catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.

catalog number base :

4713

product keywords :

IQ1 embryonic stem cells ESCs pluripotency dedifferentiation maintains cultured Wnt3a blocks differentiation PP2A Nkd Oct4 Sox2 Stem Cell Proliferation 4713, Stem cells cellular dedifferentiation totipotent pluripotent multipotent oligopotent unipotent embryonic ESC specialization specialisation specialized specialised

extended description :

Enables Wnt/ -catenin-driven expansion of ESCs; prevents spontaneous differentiation

chemical name text :

2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide

formula :

C 21 H 22 N 4 O 2

formula text :

C21H22N4O2

cas num :

331001-62-8

2020 USD :

183

2021 USD :

189 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage