IQ 1 | Tocris Bioscience 4713/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IQ 1

catalog :

4713/10

quantity :

10 mg (also 50 mg)

price :

197 USD

citations: 4

Reference
Koopmans T, Eilers R, Menzen M, Halayko A, Gosens R. ?-Catenin Directs Nuclear Factor-?B p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle. Front Immunol. 2017;8:1086 pubmed publisher
Koopmans T, Crutzen S, Menzen M, Halayko A, Hackett T, Knight D, et al. Selective targeting of CREB-binding protein/?-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle. Br J Pharmacol. 2016;173:3327-3341 pubmed publisher
Long K, Moss L, Laursen L, Boulter L, ffrench Constant C. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. Nat Commun. 2016;7:10354 pubmed publisher
Miyabayashi T, Teo J, Yamamoto M, McMillan M, Nguyen C, Kahn M. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A. 2007;104:5668-73 pubmed

product information

brand :

Tocris

master code :

4713

SKU :

4713/10

product name :

IQ 1

target :

Compounds for Induced Pluripotent Stem Cells

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

362.42

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

IQ 1 is a maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/ -catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.

extended description :

Enables Wnt/ -catenin-driven expansion of ESCs; prevents spontaneous differentiation

chemical name text :

2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide

formula :

C 21 H 22 N 4 O 2

formula text :

C21H22N4O2

cas num :

331001-62-8

USD :

197 USD

product details :

Enables Wnt/ -catenin-driven expansion of ESCs; prevents spontaneous differentiation

storage :

Store at -20°C