PF 06465469 | Tocris Bioscience 4710 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 06465469

catalog :

4710

quantity :

10 mg (also 50 mg)

price :

300 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Mamand S, Allchin R, Ahearne M, Wagner S. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep. 2018;8:14216 pubmed publisher

product information

brand :

Tocris

master code :

4710

SKU :

4710/10

product name :

PF 06465469

description :

Potent ITK inhibitor; also inhibits BTK

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

95%

observed molecular weight :

523.63

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50 = 2 nM). Also exhibits inhibitory activity against Bruton s tyrosine kinase (BTK) (IC50 = 2 nM). Displays nanomolar potencies in a cell-based IP1 assay and human whole blood assay (IC50 values are 31 and 48 nM respectively).

catalog number base :

4710

product keywords :

PF06465469 Pfizer interleukin-2 IL-2 inducible T cell kinase ITK inhibitors inhibits potent Brutons tyrosine kinase BTK Brutons Tyrosine Kinase (BTK) ITK 4710,

extended description :

Potent ITK inhibitor; also inhibits BTK

chemical name text :

(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide

formula :

C 30 H 33 N 7 O 2

formula text :

C30H33N7O2

cas num :

1407966-77-1

2020 USD :

294

2021 USD :

300 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage