product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
TC LPA5 4
catalog :
4708/10
quantity :
10 mg (also 50 mg)
price :
292 USD
more info or order :
Tocris Bioscience product webpage
citations: 3
Reference
Siriwach R, Ngo A, Higuchi M, Arima K, Sakamoto S, Watanabe A, et al. Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing. iScience. 2022;25:104130 pubmed publisher
Plastira I, Bernhart E, Goeritzer M, DeVaney T, Reicher H, Hammer A, et al. Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype. J Neuroinflammation. 2017;14:253 pubmed publisher
Kittaka H, Uchida K, Fukuta N, Tominaga M. Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1. J Physiol. 2017;595:2681-2698 pubmed publisher
product information
brand :
Tocris
catalog number base :
4708
SKU :
4708/10
product name :
TC LPA5 4
units size :
10 mg (also 50 mg)
description :
LPA5 receptor antagonist
target :
Lysophosphatidic Acid (LPA) Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
410.89
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
review stars :
5
details of functionality :
TC LPA5 4 is an LPA5 receptor antagonist (IC50 = 0.8 M in LPA5-RH7777 cells). TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelets. Exhibits selectivity for LPA5 against 80 other screened targets.
top caption :
LPA5 receptor antagonist
extended description :
LPA5 receptor antagonist
chemical name text :
5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid
formula :
C23H23ClN2O3
formula text :
C23H23ClN2O3
cas num :
1393814-38-4
USD :
292 USD
product details :
LPA5 receptor antagonist
storage :
Store at +4°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK