3-Deazaneplanocin A hydrochloride | Tocris Bioscience 4703 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

3-Deazaneplanocin A hydrochloride

catalog :

4703

quantity :

1 mg

price :

187 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Ping W, Hu J, Hu G, Song Y, Xia Q, Yao M, et al. Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs. Cell Death Dis. 2018;9:187 pubmed publisher
Wang L, Chen Y, Guan C, Zhao Z, Li Q, Yang J, et al. Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells. Stem Cell Res Ther. 2017;8:245 pubmed publisher
Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee P, et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 2007;21:1050-63 pubmed

product information

brand :

Tocris

master code :

4703

SKU :

4703/1

product name :

3-Deazaneplanocin A hydrochloride

description :

EZH2 histone methyltransferase inhibitor

target :

EZH2 Inhibitor

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

298.73

url print :

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details of functionality :

Histone methyltransferase inhibitor; decreases global histone methylation. Inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro . Induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).

catalog number base :

4703

product keywords :

3-DeazaneplanocinA NSC617989 Histone methylation inhibitors inhibits EZH2 trimethylation apoptosis s-adenosylhomocysteine hydrolase SAHH CiPSCs stem cells reprogramming induced pluripotent pluripotency PRC2 polycomb repressive complex 2 DZNep NSC 617989 Stem Cell Reprogramming Lysine Methyltransferases EZH2 4703, EZH 2, ENX 1, ENX1, KMT6, KMT 6

extended description :

EZH2 histone methyltransferase inhibitor

chemical name text :

(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride

formula :

C 12 H 14 N 4 O 3 .HCl

formula text :

C12H14N4O3.HCl

cas num :

120964-45-6

2020 USD :

178

2021 USD :

187 USD

alt names :

DZNep, NSC 617989

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage