Ro 5-3335 | Tocris Bioscience 4694/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ro 5-3335

catalog :

4694/10

quantity :

10 mg

price :

280 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Luo M, Zhou S, Feng D, Xiao J, Li W, Xu C, et al. Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock. J Biol Chem. 2016;291:22011-22020 pubmed

product information

brand :

Tocris

master code :

4694

SKU :

4694/10

rank :

0.061

product name :

Ro 5-3335

description :

Core binding factor inhibitor; attenuates hematopoiesis

target :

Additional Transcription Factor Compounds

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ro 5-3335 is a core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 M). Represses RUNX1/CBF -dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBF . Reduces leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. Also a Tat antagonist; inhibits HIV-1 replication in vitro .

extended description :

Core binding factor inhibitor; attenuates hematopoiesis

chemical name text :

7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one

formula :

C 13 H 10 ClN 3 O

formula text :

C13H10ClN3O

cas num :

30195-30-3

USD :

280 USD

product details :

Core binding factor inhibitor; attenuates hematopoiesis

alt names :

CBFβ-Runx1 inhibitor II

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage