chemical

ML 252

4687/10

10 mg (also 50 mg)

150 USD

4687

4687/10

ML 252

Potent and selective KV7.2 inhibitor; brain penetrant

Voltage-gated Potassium Channel Blockers

10 mg (also 50 mg)

Small Molecules

98%

Store at -20°C

308.43

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ML 252 is a potent and selective inhibitor of KV7.2 voltage-gated potassium channels (IC50 = 70 nM), which displays 40-fold selectivity for KV7.2 over KV7.1 channels (IC50 = 2.9 M for KV7.1). ML 252 is the ( S )-enantiomer, and is more potent than the ( R )-enantiomer or racemic mixture (IC50 values are 944 and 160 nM, respectively). ML 252 displays selectivity for KV7.2 over a panel of 68 GPCRs, ion channels and transporters; inhibits melatonin MT1 receptor 60% at 10 M. ML 252 is brain penetrant.

ML252 voltage gated potassium channel Kv7.2 inhibitor inhibits potent brain penetrant selective Voltage-Gated Potassium Channels 4687,

Potent and selective KV7.2 inhibitor; brain penetrant

(S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide

C20H24N2O

C20H24N2O

1392494-64-2

148

150 USD

Potent and selective KV7.2 inhibitor; brain penetrant