4686/10 | Tocris Bioscience 4686/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4686/10

catalog :

4686/10

quantity :

10 mg

price :

254 USD

citations: 2

Reference
Walden D, Kunnimalaiyaan S, Sokolowski K, Clark T, Kunnimalaiyaan M. Antiproliferative and apoptotic effects of xanthohumol in cholangiocarcinoma. Oncotarget. 2017;8:88069-88078 pubmed publisher
den Brok M, Bull C, Wassink M, de Graaf A, Wagenaars J, Minderman M, et al. Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation. Nat Commun. 2016;7:13324 pubmed publisher

product information

master code :

4686

SKU :

4686/10

product name :

Xanthohumol

unit size :

10 mg

description :

p97 ATPase (VCP) inhibitor

target :

Other ER Stress/UPR Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

354.4

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Xanthohumol is a p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 M).

top caption :

p97 ATPase (VCP) inhibitor

extended description :

p97 ATPase (VCP) inhibitor

chemical name text :

(2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

formula :

C21H22O5

formula text :

C21H22O5

cas num :

6754-58-1

USD :

254 USD

product details :

p97 ATPase (VCP) inhibitor

storage :

Store at +4░C