product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
CYM 50358 hydrochloride
catalog :
4679/10
quantity :
10 mg (also 50 mg)
price :
303 USD
more info or order :
Tocris Bioscience product webpage
citations: 3
Reference
Wang Y, Wang C, He Q, Chen G, Yu J, Cang J, et al. Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux. Front Immunol. 2023;14:1090202 pubmed publisher
Cautivo K, Matatia P, Lizama C, Mroz N, Dahlgren M, Yu X, et al. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity. 2022;55:254-271.e7 pubmed publisher
Drouillard A, Neyra A, Mathieu A, Marcais A, Wencker M, Marvel J, et al. Human Naive and Memory T Cells Display Opposite Migratory Responses to Sphingosine-1 Phosphate. J Immunol. 2018;200:551-557 pubmed publisher
product information
brand :
Tocris
catalog number base :
4679
SKU :
4679/10
product name :
CYM 50358 hydrochloride
units size :
10 mg (also 50 mg)
description :
Potent and selective S1P4 antagonist
target :
Sphingosine-1-phosphate Receptor Antagonists
category :
Small Molecules
purity :
97%
observed molecular weight :
425.74
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CYM 50358 hydrochloride is a potent S1P4 antagonist (IC50 = 25 nM). Displays selectivity for S1P4 against S1P1, S1P2, S1P3 and S1P5 receptors.
top caption :
Potent and selective S1P4 antagonist
extended description :
Potent and selective S1P4 antagonist
chemical name text :
N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride
formula :
C20H18Cl2N2O2.HCl
formula text :
C20H18Cl2N2O2.HCl
cas num :
1781750-72-8
USD :
303 USD
product details :
Potent and selective S1P4 antagonist
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK