chemical

SB 223412

4672

10 mg (also 50 mg)

208 USD

4672

4672/10

SB 223412

Potent, selective non-peptide NK3 antagonist. Brain penetrant

NK3 Receptor Antagonists

Small Molecules

10 mg (also 50 mg)

98%

382.45

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Potent and selective non-peptide NK3 receptor antagonist (Ki values are 1, 144 and 100000 nM for human NK3, NK2 and NK1 receptors respectively). Selective over a panel of 60 receptors, enzymes and ion channels at concentrations of 1 or 10 M. Inhibits NKB-induced Ca2+ mobilization in vitro (IC50 = 16.6 nM) and inhibits NK3-agonist-induced behavioral responses in vivo . Orally active and brain penetrant.

4672

SB223412 Potent selective non-peptide NK3 antagonists Brain penetrant Tachykinin Receptors Neurokinin orally active NK3 Receptor 4672,

Potent, selective non-peptide NK3 antagonist. Brain penetrant

3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide

C 25 H 22 N 2 O 2

174636-32-9

203

208 USD

Store at +4°C