Floxuridine | Tocris Bioscience 4659/50 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Floxuridine

catalog :

4659/50

quantity :

50 mg

price :

97 USD

citations: 2

Reference
Tiwari S, Dang J, Qin Y, Lichinchi G, Bansal V, Rana T. Zika virus infection reprograms global transcription of host cells to allow sustained infection. Emerg Microbes Infect. 2017;6:e24 pubmed publisher
Huehls A, Wagner J, Huntoon C, Geng L, Erlichman C, Patel A, et al. Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 2011;71:4944-54 pubmed publisher

product information

brand :

Tocris

master code :

4659

SKU :

4659/50

product name :

Floxuridine

description :

Thymidylate synthetase inhibitor

target :

Thymidylate Synthetase Inhibitor

category :

Small Molecules

unit sizes :

50 mg

purity :

98%

observed molecular weight :

246.19

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Floxuridine is an antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

extended description :

Thymidylate synthetase inhibitor

chemical name text :

5-Fluoro-2 -deoxyuridine

formula :

C 9 H 11 FN 2 O 5

formula text :

C9H11FN2O5

cas num :

50-91-9

USD :

97 USD

product details :

Thymidylate synthetase inhibitor

alt names :

FdUrd

storage :

Store at RT