ML 171 | Tocris Bioscience 4653 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 171

catalog :

4653

quantity :

50 mg

price :

69 USD

citations: 4

Reference
Moon J, Nakahira K, Chung K, DeNicola G, Koo M, Pabón M, et al. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nat Med. 2016;22:1002-12 pubmed publisher
Shen K, Lu F, Xie J, Wu M, Cai B, Liu Y, et al. Cambogin exerts anti-proliferative and pro-apoptotic effects on breast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics. Oncotarget. 2016;7:50596-50611 pubmed publisher
Hood K, Montezano A, Harvey A, Nilsen M, MacLean M, Touyz R. Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16?-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension. Hypertension. 2016;68:796-808 pubmed publisher
Cheung E, Lee P, Ceteci F, Nixon C, Blyth K, Sansom O, et al. Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes Dev. 2016;30:52-63 pubmed publisher

product information

brand :

Tocris

master code :

4653

SKU :

4653/50

product name :

ML 171

description :

Selective NADPH oxidase 1 (NOX1) inhibitor

target :

NADPH Oxidase Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

241.31

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NADPH oxidase 1 (NOX1) inhibitor; blocks NOX1-dependent ROS generation (IC50 = 0.25 M in a HEK293-NOX1 recombinant cell system). Selective for NOX1 over other NADPH oxidases (IC50 values are 3 M). Inhibits SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.

catalog number base :

4653

product keywords :

ML171 NADPH oxidases 1 NOX1 reactive oxygen species ROS inhibits inhibitors selective cell permeable NADPH Oxidase 4653,

extended description :

Selective NADPH oxidase 1 (NOX1) inhibitor

chemical name text :

2-Acetylphenothiazine

formula :

C 14 H 11 NOS

formula text :

C14H11NOS

cas num :

6631-94-3

2020 USD :

2021 USD :

69 USD

storage :

Store at +4°C