JW 67 | Tocris Bioscience 4651/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JW 67

catalog :

4651/10

quantity :

10 mg (also 50 mg)

price :

209 USD

product information

brand :

Tocris

MasterCode :

4651

SKU :

4651/10

product name :

JW 67

target :

Other Wnt Signaling Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

394.38

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 M); targets the -catenin destruction complex (GSK-3 /AXIN/APC) to induce -catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF- B pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 M).

extended description :

Wnt pathway inhibitor; induces degradation of active -catenin

chemical name text :

Trispiro[3H-indole-3,2 -[1,3]dioxane-2 ,3 -[3H]indole]-2,2 (1H,1 H)-dione

formula :

C 21 H 18 N 2 O 6

formula text :

C21H18N2O6

cas num :

442644-28-2

USD :

209 USD

product details :

Wnt pathway inhibitor; induces degradation of active -catenin

storage :

Store at +4°C