I-BET 151 dihydrochloride | Tocris Bioscience 4650/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

I-BET 151 dihydrochloride

catalog :

4650/10

quantity :

10 mg (also 50 mg)

price :

297 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Xie X, Jankauskas R, Mazari A, Drou N, Percipalle P. β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. PLoS Genet. 2018;14:e1007846 pubmed publisher
Bowry A, Piberger A, Rojas P, Saponaro M, Petermann E. BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication. Cell Rep. 2018;25:2061-2069.e4 pubmed publisher
Shao Z, Yao C, Khodadadi Jamayran A, Xu W, Townes T, Crowley M, et al. Reprogramming by De-bookmarking the Somatic Transcriptional Program through Targeting of BET Bromodomains. Cell Rep. 2016;16:3138-3145 pubmed publisher
Kumar K, Raza S, Knab L, Chow C, Kwok B, Bentrem D, et al. GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1. Sci Rep. 2015;5:9489 pubmed publisher

product information

brand :

Tocris

master code :

4650

SKU :

4650/10

rank :

0.061

product name :

I-BET 151 dihydrochloride

description :

BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes

target :

Bromodomain Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

I-BET 151 dihydrochloride is a BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively); reduces BCL2 expression in NOMO1 cells. Improves survival in two rodent models of MLL-fusion leukemia in vivo . Enhances differentiation of human iPSC into megakaryocytes. Also enhances fibroblast reprogramming to hiPSCs at low concentration. . For more information about how I-BET 151 dihydrochloride may be used, see our protocol: Transdifferentiating Fibroblasts into Neurons .

extended description :

BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes

chemical name text :

7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride

formula :

C 23 H 21 N 5 O 3 .2HCl

formula text :

C23H21N5O3.2HCl

cas num :

1883545-47-8

USD :

297 USD

product details :

BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage