Elacridar hydrochloride | Tocris Bioscience 4646 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Elacridar hydrochloride

catalog :

4646

quantity :

10 mg

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Lahmann C, Kramer H, Ashcroft F. Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents. PLoS ONE. 2015;10:e0134476 pubmed publisher
Jablonski M, Markandaiah S, Jacob D, Meng N, Li K, Gennaro V, et al. Inhibiting drug efflux transporters improves efficacy of ALS therapeutics. Ann Clin Transl Neurol. 2014;1:996-1005 pubmed publisher
Ramesh R, Kozhaya L, McKevitt K, Djuretic I, Carlson T, Quintero M, et al. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. J Exp Med. 2014;211:89-104 pubmed publisher

product information

brand :

Tocris

master code :

4646

SKU :

4646/10

product name :

Elacridar hydrochloride

description :

P-gp inhibitor

target :

Multidrug Transporter Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

600.1

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active.

catalog number base :

4646

product keywords :

GF120918 P-glycoprotein P-gp inhibitors inhibits multidrug resistance MDR BCRP ABCG1 ABCG2 ABCB1 GF 120918 Multidrug Transporters 4646,

extended description :

P-gp inhibitor

chemical name text :

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride

formula :

C 34 H 33 N 3 O 5 .HCl

formula text :

C34H33N3O5.HCl

cas num :

143851-98-3

2020 USD :

228

2021 USD :

238 USD

alt names :

GF 120918

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage