Elacridar hydrochloride | Tocris Bioscience 4646/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Elacridar hydrochloride

catalog :

4646/10

quantity :

10 mg

price :

276 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Lahmann C, Kramer H, Ashcroft F. Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents. PLoS ONE. 2015;10:e0134476 pubmed publisher
Jablonski M, Markandaiah S, Jacob D, Meng N, Li K, Gennaro V, et al. Inhibiting drug efflux transporters improves efficacy of ALS therapeutics. Ann Clin Transl Neurol. 2014;1:996-1005 pubmed publisher
Ramesh R, Kozhaya L, McKevitt K, Djuretic I, Carlson T, Quintero M, et al. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. J Exp Med. 2014;211:89-104 pubmed publisher

product information

brand :

Tocris

master code :

4646

SKU :

4646/10

rank :

0.061

product name :

Elacridar hydrochloride

description :

P-gp and BCRP inhibitor

target :

Multidrug Transporter Inhibitors

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Elacridar hydrochloride is a P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) inhibitor. Elacridar hydrochloride blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Orally active.

extended description :

P-gp and BCRP inhibitor

chemical name text :

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride

formula :

C 34 H 33 N 3 O 5 .HCl

formula text :

C34H33N3O5.HCl

cas num :

143851-98-3

USD :

276 USD

product details :

P-gp and BCRP inhibitor

alt names :

GF 120918

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage