4-CMTB | Tocris Bioscience 4642 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4-CMTB

catalog :

4642

quantity :

10 mg (also 50 mg)

price :

184 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Marinelli L, Martin Gallausiaux C, Bourhis J, Béguet Crespel F, Blottiere H, Lapaque N. Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells. Sci Rep. 2019;9:643 pubmed publisher
Martin Gallausiaux C, Larraufie P, Jarry A, Béguet Crespel F, Marinelli L, Ledue F, et al. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol. 2018;9:2838 pubmed publisher
Martin Gallausiaux C, Béguet Crespel F, Marinelli L, Jamet A, Ledue F, Blottiere H, et al. Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells. Sci Rep. 2018;8:9742 pubmed publisher

product information

brand :

Tocris

master code :

4642

SKU :

4642/10

product name :

4-CMTB

description :

FFA2 agonist; also exhibits positive allosteric modulatory activity

target :

Free Fatty Acid Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

294.8

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Free fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

catalog number base :

4642

product keywords :

free fatty acid receptors FFA FFA2 agonists positive allosteric modulators pams Free Fatty Acid Receptors 4642,

extended description :

FFA2 agonist; also exhibits positive allosteric modulatory activity

chemical name text :

4-chloro- -(1-methylethyl)-N-2-thiazolylbenzeneacetamide

formula :

C 14 H 15 ClN 2 OS

formula text :

C14H15ClN2OS

cas num :

300851-67-6

2020 USD :

176

2021 USD :

184 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage