SB 747651A dihydrochloride | Tocris Bioscience 4630 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 747651A dihydrochloride

catalog :

4630

quantity :

10 mg

price :

283 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Lopes A, van Roon J, Blokland S, Wang M, Chouri E, Hartgring S, et al. MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1. Front Immunol. 2019;10:1335 pubmed publisher
Jones D, Jenney A, Joughin B, Sorger P, Lauffenburger D. Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Sci Signal. 2018;11: pubmed publisher
Tochiki K, MaiarÃº M, Norris C, Hunt S, GÃ©ranton S. The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour. Pain. 2016;157:2594-2604 pubmed

product information

brand :

Tocris

master code :

4630

SKU :

4630/10

product name :

SB 747651A dihydrochloride

description :

Potent MSK1 inhibitor; also inhibits other AGC group kinases

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

415.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. Blocks IL-10 production in macrophages.

catalog number base :

4630

product keywords :

SB747651A mitogen and stress activated kinase inhibitors inhibits MSK1 MSK2 potent IL-10 production cell permeable AGC group Other Kinases 4630,

extended description :

Potent MSK1 inhibitor; also inhibits other AGC group kinases

chemical name text :

2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride

formula :

C 16 H 22 N 8 O.2HCl

formula text :

C16H22N8O.2HCl

cas num :

1781882-72-1

2020 USD :

272

2021 USD :

283 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage