4630/10 | Tocris Bioscience 4630/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4630/10

catalog :

4630/10

quantity :

10 mg

price :

368 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Huang S, Taylor C, Zahradka P. Growth State-Dependent Activation of eNOS in Response to DHA: Involvement of p38 MAPK. Int J Mol Sci. 2023;24: pubmed publisher
Farnsworth D, Inoue Y, Johnson F, de Rappard Yuswack G, Lu D, Shi R, et al. MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression. NPJ Precis Oncol. 2022;6:88 pubmed publisher
Inoue Y, Nikolic A, Farnsworth D, Shi R, Johnson F, Liu A, et al. Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer. elife. 2021;10: pubmed publisher
Lee W, Lavery L, Rousseaux M, Rutledge E, Jang Y, Wan Y, et al. Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1. EMBO J. 2021;40:e106106 pubmed publisher
Lopes A, van Roon J, Blokland S, Wang M, Chouri E, Hartgring S, et al. MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1. Front Immunol. 2019;10:1335 pubmed publisher
PEREZ ORTIZ J, Mollema N, Toker N, Adamski C, O Callaghan B, Duvick L, et al. Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model. Neurobiol Dis. 2018;116:93-105 pubmed publisher
Jones D, Jenney A, Joughin B, Sorger P, Lauffenburger D. Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Sci Signal. 2018;11: pubmed publisher
Kawasaki S, Abe N, Ohtake F, Islam A, Choudhury M, Utsunomiya R, et al. Effects of hypnotic bromovalerylurea on microglial BV2 cells. J Pharmacol Sci. 2017;134:116-123 pubmed publisher
Tochiki K, MaiarÃº M, Norris C, Hunt S, GÃ©ranton S. The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour. Pain. 2016;157:2594-2604 pubmed
Hsu K, Guan B, Cheng X, Guan D, Lam M, Hatzoglou M, et al. Translational control of PML contributes to TNFÎ±-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs. Cell Death Differ. 2016;23:469-83 pubmed publisher

product information

master code :

4630

SKU :

4630/10

product name :

SB 747651A dihydrochloride

unit size :

10 mg

description :

Potent MSK1 inhibitor; also inhibits other AGC group kinases

target :

Other Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

415.32

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 747651A dihydrochloride is a potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. Blocks IL-10 production in macrophages.

top caption :

Potent MSK1 inhibitor; also inhibits other AGC group kinases

extended description :

Potent MSK1 inhibitor; also inhibits other AGC group kinases

chemical name text :

2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride

formula :

C16H22N8O.2HCl

formula text :

C16H22N8O.2HCl

cas num :

1781882-72-1

USD :

368 USD

product details :

Potent MSK1 inhibitor; also inhibits other AGC group kinases

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage