MK 1903 | Tocris Bioscience 4622 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MK 1903

catalog :

4622

quantity :

10 mg (also 50 mg)

price :

229 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Marinelli L, Martin Gallausiaux C, Bourhis J, Béguet Crespel F, Blottiere H, Lapaque N. Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells. Sci Rep. 2019;9:643 pubmed publisher
Martin Gallausiaux C, Larraufie P, Jarry A, Béguet Crespel F, Marinelli L, Ledue F, et al. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol. 2018;9:2838 pubmed publisher

product information

brand :

Tocris

master code :

4622

SKU :

4622/10

product name :

MK 1903

description :

Potent and selective GPR109A (HCA2) agonist

target :

Nicotinic Acid Receptor (GPR109) Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

164.16

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective hydroxycarboxylic acid receptor 2 (HCA2, GPR109A) full agonist; exhibits greater potency than niacin in a whole cell HTRF-cAMP assay (EC50 values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor.

catalog number base :

4622

product keywords :

MK1903 HCA2 hydroxycarboxylic acid receptors GPR109A HM74A agonists Hydroxycarboxylic Acid Receptors 4622,

extended description :

Potent and selective GPR109A (HCA2) agonist

chemical name text :

(4aR,5aR)-4,4a,5,5a-Tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2]pyrazole-3-carboxylic acid

formula :

C 8 H 8 N 2 O 2

cas num :

1268882-43-4

2020 USD :

222

2021 USD :

229 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage