product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
4622/10
catalog :
4622/10
quantity :
10 mg
price :
288 USD
more info or order :
citations: 4
Reference
Perrone M, Pagano M, Belardo C, Ricciardi F, Ricciardi F, Fusco A, et al. Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1). Neuropharmacology. 2023;228:109456 pubmed publisher
Kalkan H, Pagano E, Paris D, Panza E, Cuozzo M, Moriello C, et al. Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy. EMBO Mol Med. 2023;15:e16225 pubmed publisher
Marinelli L, Martin Gallausiaux C, Bourhis J, Béguet Crespel F, Blottiere H, Lapaque N. Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells. Sci Rep. 2019;9:643 pubmed publisher
Martin Gallausiaux C, Larraufie P, Jarry A, Béguet Crespel F, Marinelli L, Ledue F, et al. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol. 2018;9:2838 pubmed publisher
product information
master code :
4622
SKU :
4622/10
product name :
MK 1903
unit size :
10 mg
description :
Potent and selective GPR109A (HCA2) agonist
target :
Nicotinic Acid Receptor (GPR109) Agonists
category :
Small Molecules
purity :
98%
observed molecular weight :
164.16
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MK 1903 is a potent and selective hydroxycarboxylic acid receptor 2 (HCA2, GPR109A) full agonist; exhibits greater potency than niacin in a whole cell HTRF-cAMP assay (EC50 values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor.
top caption :
Potent and selective GPR109A (HCA2) agonist
extended description :
Potent and selective GPR109A (HCA2) agonist
chemical name text :
(4aR,5aR)-4,4a,5,5a-Tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2]pyrazole-3-carboxylic acid
formula :
C8H8N2O2
cas num :
1268882-43-4
USD :
288 USD
product details :
Potent and selective GPR109A (HCA2) agonist
storage :
Store at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK