4621/10 | Tocris Bioscience 4621/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4621/10

catalog :

4621/10

quantity :

10 mg (also 50 mg)

price :

281 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kim Chiaw P, Hantouche C, Wong M, Matthes E, Robert R, Hanrahan J, et al. Hsp70 and DNAJA2 limit CFTR levels through degradation. PLoS ONE. 2019;14:e0220984 pubmed publisher

product information

master code :

4621

SKU :

4621/10

product name :

MKT 077

unit size :

10 mg (also 50 mg)

description :

Binds mot-2; selectively cytotoxic in cancer cells

target :

HSP70 Modulators

category :

Small Molecules

purity :

98%

observed molecular weight :

432

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MKT 077 is an occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.

top caption :

Binds mot-2; selectively cytotoxic in cancer cells

extended description :

Binds mot-2; selectively cytotoxic in cancer cells

chemical name text :

1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride

formula :

C21H22ClN3OS2

formula text :

C21H22ClN3OS2

cas num :

147366-41-4

USD :

281 USD

product details :

Binds mot-2; selectively cytotoxic in cancer cells

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage