| Reference |
|---|
Yuan B, Shi K, Zha J, Cai Y, Gu Y, Huang K, et al. Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis. 2023;14:51 pubmed publisher |
Kumari R, Ray A, Mukherjee D, Chander V, Kar D, Kumar U, et al. Downregulation of PTEN Promotes Autophagy via Concurrent Reduction in Apoptosis in Cardiac Hypertrophy in PPAR α-/- Mice. Front Cardiovasc Med. 2022;9:798639 pubmed publisher |
Mishra S, Sadagopan N, Dunkerly Eyring B, Rodriguez S, Sarver D, Ceddia R, et al. Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice. J Clin Invest. 2021;131: pubmed publisher |
S xe1 ez Orellana F, Leroy T, Ribeiro F, Kreis A, Leroy K, Lalloyer F, et al. Regulation of PPARα by APP in Alzheimer disease affects the pharmacological modulation of synaptic activity. JCI Insight. 2021;6: pubmed publisher |
Mana M, Hussey A, Tzouanas C, Imada S, Barrera Millan Y, Bahceci D, et al. High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity. Cell Rep. 2021;35:109212 pubmed publisher |
Zhang Y, Cao X, Chen L, Qin Y, Xu Y, Tian Y, et al. Exposure of female mice to perfluorooctanoic acid suppresses hypothalamic kisspeptin-reproductive endocrine system through enhanced hepatic fibroblast growth factor 21 synthesis, leading to ovulation failure and prolonged dioestrus. J Neuroendocrinol. 2020;32:e12848 pubmed publisher |
Corbet C, Bastien E, Santiago de Jesus J, Dierge E, Martherus R, Vander Linden C, et al. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. Nat Commun. 2020;11:454 pubmed publisher |
Smith D, Martinelli R, Besra G, Illarionov P, Szatmari I, Brazda P, et al. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology (Berl). 2019;: pubmed publisher |
Chen T, Lee R, Tsai S, Kanamaluru D, Gray N, Yiv N, et al. An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice. J Biol Chem. 2019;294:9213-9224 pubmed publisher |
Wang H, Mao X, Du M. Phytanic acid activates PPARα to promote beige adipogenic differentiation of preadipocytes. J Nutr Biochem. 2019;67:201-211 pubmed publisher |
Guo B, Huang X, Lee M, Lee S, Broxmeyer H. Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat Med. 2018;24:360-367 pubmed publisher |
Yamaguchi S, Moseley A, Almeda Valdes P, Stromsdorfer K, Franczyk M, Okunade A, et al. Diurnal Variation in PDK4 Expression Is Associated With Plasma Free Fatty Acid Availability in People. J Clin Endocrinol Metab. 2018;103:1068-1076 pubmed publisher |
Neuhaus W, Kramer T, Neuhoff A, Gölz C, Thal S, Förster C. Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury. Front Mol Neurosci. 2017;10:149 pubmed publisher |
Qian G, Fan W, Ahlemeyer B, Karnati S, Baumgart Vogt E. Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors. PLoS ONE. 2015;10:e0143439 pubmed publisher |
Helmy M, Helmy M, El Mas M. Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs. PLoS ONE. 2015;10:e0142303 pubmed publisher |
Oruqaj G, Karnati S, Vijayan V, Kotarkonda L, Boateng E, Zhang W, et al. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A. 2015;112:E2048-57 pubmed publisher |
Abu Aboud O, Donohoe D, Bultman S, Fitch M, Riiff T, Hellerstein M, et al. PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth. Am J Physiol Cell Physiol. 2015;308:C890-8 pubmed publisher |
Lin T, Lu C, Wu C, Huang S, Wang S. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Int J Mol Sci. 2015;16:5555-71 pubmed publisher |
Hsu Y, Wang L, Yang W, Yang C, Yang C. Effects of fenofibrate on adiponectin expression in retinas of streptozotocin-induced diabetic rats. J Diabetes Res. 2014;2014:540326 pubmed publisher |
Kim Y, Park K, Kim J, Seo H, Shin K, Lee Y, et al. An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. Mol Cell Biol. 2014;34:4368-78 pubmed publisher |
Borrelli F, Romano B, Petrosino S, Pagano E, Capasso R, Coppola D, et al. Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent. Br J Pharmacol. 2015;172:142-58 pubmed publisher |
Midgett K, Peden Adams M, Gilkeson G, Kamen D. In vitro evaluation of the effects of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on IL-2 production in human T-cells. J Appl Toxicol. 2015;35:459-65 pubmed publisher |
Redlich S, Ribes S, Schütze S, Nau R. Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections. J Neuroinflammation. 2014;11:108 pubmed publisher |
Capasso R, Orlando P, Pagano E, Aveta T, Buono L, Borrelli F, et al. Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB₁ receptors and TRPV1 channels. Br J Pharmacol. 2014;171:4026-37 pubmed publisher |
Shih C, Lin I, Ding J, Chen F, Chou T. Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity. Br J Pharmacol. 2014;171:1490-1500 pubmed publisher |
Li T, Zhang Q, Zhang J, Yang G, Shao Z, Luo J, et al. Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-?B pathway. BMC Cancer. 2014;14:96 pubmed publisher |
Okine B, Rea K, Olango W, Price J, Herdman S, Madasu M, et al. A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats. Br J Pharmacol. 2014;171:1462-71 pubmed publisher |
El Sisi A, Hegazy S, El Khateeb E. Effects of three different fibrates on intrahepatic cholestasis experimentally induced in rats. PPAR Res. 2013;2013:781348 pubmed publisher |
Crane D, Ireland R, Alinger J, Small P, Bosio C. Lipids derived from virulent Francisella tularensis broadly inhibit pulmonary inflammation via toll-like receptor 2 and peroxisome proliferator-activated receptor ?. Clin Vaccine Immunol. 2013;20:1531-40 pubmed publisher |
Kok B, Dyck J, Harris T, Brindley D. Differential regulation of the expressions of the PGC-1? splice variants, lipins, and PPAR? in heart compared to liver. J Lipid Res. 2013;54:1662-77 pubmed publisher |
Ambrosino P, Soldovieri M, Russo C, Taglialatela M. Activation and desensitization of TRPV1 channels in sensory neurons by the PPAR? agonist palmitoylethanolamide. Br J Pharmacol. 2013;168:1430-44 pubmed publisher |
Carracedo A, Weiss D, Leliaert A, Bhasin M, de Boer V, Laurent G, et al. A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012;122:3088-100 pubmed publisher |
Mottillo E, Bloch A, Leff T, Granneman J. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply. J Biol Chem. 2012;287:25038-48 pubmed publisher |
Downer E, Clifford E, Amu S, Fallon P, Moynagh P. The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α. J Biol Chem. 2012;287:25440-53 pubmed publisher |
Hamtiaux L, Masquelier J, Muccioli G, Bouzin C, Feron O, Gallez B, et al. The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action. BMC Cancer. 2012;12:92 pubmed publisher |
Kong L, Ren W, Li W, Zhao S, Mi H, Wang R, et al. Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice. Lipids Health Dis. 2011;10:246 pubmed publisher |
Hamtiaux L, Hansoulle L, Dauguet N, Muccioli G, Gallez B, Lambert D. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. PLoS ONE. 2011;6:e26823 pubmed publisher |
Bumpus N, Johnson E. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated pro. J Pharmacol Exp Ther. 2011;339:886-95 pubmed publisher |
Poleni P, Etienne S, Velot E, Netter P, Bianchi A. Activation of PPARs α, β/δ, and γ Impairs TGF-β1-Induced Collagens' Production and Modulates the TIMP-1/MMPs Balance in Three-Dimensional Cultured Chondrocytes. PPAR Res. 2010;2010:635912 pubmed publisher |
