Penitrem A | Tocris Bioscience 4617 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Penitrem A

catalog :

4617

quantity :

1 mg

price :

116 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Khan N, Lakpa K, Halcrow P, Afghah Z, Miller N, Geiger J, et al. BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation. Sci Rep. 2019;9:12285 pubmed publisher
Abrahao K, Chancey J, Chan C, Lovinger D. Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus. Neuropsychopharmacology. 2017;42:1070-1081 pubmed publisher
Hirono M, Ogawa Y, Misono K, Zollinger D, Trimmer J, Rasband M, et al. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J Neurosci. 2015;35:7082-94 pubmed publisher

product information

brand :

Tocris

master code :

4617

SKU :

4617/1

product name :

Penitrem A

description :

Potent and selective KCa1.1 (BK) channel blocker

target :

Ca2+-Activated Potassium Channel Blockers

category :

Small Molecules

unit size :

1 mg

purity :

95%

observed molecular weight :

634.2

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective blocker of BKCa (KCa1.1) channels (IC50 values are 6.4 and 64.4 nM for BKCa channels containing subunits only, and those containing and 1 respectively). Displays no effect on native delayed rectifier K+ and KATP currents, or cloned KV1.5 channels. Blocks BKCa channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo .

catalog number base :

4617

product keywords :

PenitremA maxi-k bk channels potent selective inhibitors inhibits blockers slo KCa KCa1.1 K+ high conductance Ca2+-dependent Potassium Ca2+-activated Ca2+-dependent Ca2+-Activated Potassium Channels 4617,

extended description :

Potent and selective KCa1.1 (BK) channel blocker

chemical name text :

2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4 ,4 a]-1-b

formula :

C 37 H 44 ClNO 6

formula text :

C37H44ClNO6

cas num :

12627-35-9

2020 USD :

113

2021 USD :

116 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage