4617/1 | Tocris Bioscience 4617/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4617/1

catalog :

4617/1

quantity :

1 mg

price :

147 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Khan N, Lakpa K, Halcrow P, Afghah Z, Miller N, Geiger J, et al. BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation. Sci Rep. 2019;9:12285 pubmed publisher
Abrahao K, Chancey J, Chan C, Lovinger D. Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus. Neuropsychopharmacology. 2017;42:1070-1081 pubmed publisher
Hirono M, Ogawa Y, Misono K, Zollinger D, Trimmer J, Rasband M, et al. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J Neurosci. 2015;35:7082-94 pubmed publisher

product information

master code :

4617

SKU :

4617/1

product name :

Penitrem A

unit size :

1 mg

description :

Potent and selective KCa1.1 (BK) channel blocker

target :

Ca2+-Activated Potassium Channel Blockers

category :

Small Molecules

purity :

95%

observed molecular weight :

634.2

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Penitrem A is a potent and selective blocker of BKCa (KCa1.1) channels (IC50 values are 6.4 and 64.4 nM for BKCa channels containing subunits only, and those containing and 1 respectively). Displays no effect on native delayed rectifier K+ and KATP currents, or cloned KV1.5 channels. Blocks BKCa channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo .

top caption :

Potent and selective KCa1.1 (BK) channel blocker

extended description :

Potent and selective KCa1.1 (BK) channel blocker

chemical name text :

2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4 ,4 a]-1-b

formula :

C37H44ClNO6

formula text :

C37H44ClNO6

cas num :

12627-35-9

USD :

147 USD

product details :

Potent and selective KCa1.1 (BK) channel blocker

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage