BMS 303141 | Tocris Bioscience 4609 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BMS 303141

catalog :

4609

quantity :

10 mg (also 50 mg)

price :

197 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Márquez S, Fernández J, Mancebo C, Herrero Sanchez C, Alonso S, Sandoval T, et al. Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns. Cell Rep. 2019;27:525-536.e4 pubmed publisher
Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, et al. Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase. Front Immunol. 2018;9:2858 pubmed publisher
Shah S, Carriveau W, Li J, Campbell S, Kopinski P, Lim H, et al. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. Oncotarget. 2016;7:43713-43730 pubmed publisher

product information

brand :

Tocris

master code :

4609

SKU :

4609/10

product name :

BMS 303141

description :

ATP citrate lyase inhibitor; orally bioavailable

target :

Other Transferase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

424.3

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 M for human recombinant ACL); blocks lipid synthesis (IC50 = 8 M in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 M. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable.

catalog number base :

4609

product keywords :

BMS303141 ATP citrate lyases inhibits inhibitors plasma glucose triglycerides orally bioavailable synthases transferases ACLY ATP Citrate Lyase 4609,

extended description :

ATP citrate lyase inhibitor; orally bioavailable

chemical name text :

3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1 -biphenyl]-3-yl)-benzenesulfonamide

formula :

C 19 H 15 Cl 2 NO 4 S

formula text :

C19H15Cl2NO4S

cas num :

943962-47-8

2020 USD :

187

2021 USD :

197 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage