4609/10 | Tocris Bioscience 4609/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4609/10

catalog :

4609/10

quantity :

10 mg (also 50 mg)

price :

249 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Wartewig T, Daniels J, Schulz M, Hameister E, Joshi A, Park J, et al. PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma. Nat Cancer. 2023;4:1508-1525 pubmed publisher
Dominguez M, Truemper V, Mota A, Br xfc ne B, Namgaladze D. Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells. Front Immunol. 2022;13:906127 pubmed publisher
Puleston D, Baixauli F, Sanin D, Edwards Hicks J, Villa M, Kabat A, et al. Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell. 2021;184:4186-4202.e20 pubmed publisher
Jones N, Blagih J, Zani F, Rees A, Hill D, Jenkins B, et al. Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation. Nat Commun. 2021;12:1209 pubmed publisher
Møller S, Mellergaard M, Madsen M, Bermejo A, Jepsen S, Hansen M, et al. Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells. Front Immunol. 2020;11:1968 pubmed publisher
Li Z, Zhang H, Huang Y, Huang J, Sun P, Zhou N, et al. Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation. Nat Commun. 2020;11:3806 pubmed publisher
Márquez S, Fernández J, Mancebo C, Herrero Sanchez C, Alonso S, Sandoval T, et al. Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns. Cell Rep. 2019;27:525-536.e4 pubmed publisher
Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, et al. Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase. Front Immunol. 2018;9:2858 pubmed publisher
Shah S, Carriveau W, Li J, Campbell S, Kopinski P, Lim H, et al. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. Oncotarget. 2016;7:43713-43730 pubmed publisher

product information

master code :

4609

SKU :

4609/10

product name :

BMS 303141

unit size :

10 mg (also 50 mg)

description :

ATP citrate lyase inhibitor; orally bioavailable

target :

ATP Citrate Lyase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

424.3

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BMS 303141 is an ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 M for human recombinant ACL); blocks lipid synthesis (IC50 = 8 M in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 M. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia; reduces cell proliferation in HepG2 and Huh-7 cell lines and in PD-1 deficient lymphomas. Orally bioavailable.

top caption :

ATP citrate lyase inhibitor; orally bioavailable

extended description :

ATP citrate lyase inhibitor; orally bioavailable

chemical name text :

3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1 -biphenyl]-3-yl)-benzenesulfonamide

formula :

C19H15Cl2NO4S

formula text :

C19H15Cl2NO4S

cas num :

943962-47-8

USD :

249 USD

product details :

ATP citrate lyase inhibitor; orally bioavailable

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage