PHT 427 | Tocris Bioscience 4598 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PHT 427

catalog :

4598

quantity :

10 mg (also 50 mg)

price :

104 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Meuillet E, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, et al. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010;9:706-17 pubmed publisher

product information

brand :

Tocris

master code :

4598

SKU :

4598/10

product name :

PHT 427

description :

Dual Akt and PDK1 inhibitor; antitumor

target :

Akt (Protein Kinase B) Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

409.61

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 M, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro . Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

catalog number base :

4598

product keywords :

PHT427 Phosphatidylinositol 3-kinase/phosphatidylinositide-dependent protein kinase 1 PDPK1Akt, pleckstrin homology PH domain AKT inhibitors inhibits antitumor duel tumour PDK1 Akt (Protein Kinase B) Protein Kinase B/Akt PDK1 Phosphoinositide-dependent Kinase 1 4598,

extended description :

Dual Akt and PDK1 inhibitor; antitumor

chemical name text :

4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide

formula :

C 20 H 31 N 3 O 2 S 2

cas num :

1191951-57-1

2020 USD :

104

2021 USD :

104 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage