NS 8593 hydrochloride | Tocris Bioscience 4597 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NS 8593 hydrochloride

catalog :

4597

quantity :

10 mg (also 50 mg)

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Tian Y, Yang T, Yu S, Liu C, He M, Hu C. Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels. J Cell Mol Med. 2018;22:6327-6337 pubmed publisher

product information

brand :

Tocris

master code :

4597

SKU :

4597/10

product name :

NS 8593 hydrochloride

description :

Selective negative modulator of KCa2 (SK) channels; inhibits SK currents

target :

Ca2+-Activated Potassium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

299.8

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 M for SK1, SK2 and SK3 respectively at 0.5 M Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.

catalog number base :

4597

product keywords :

NS8593 hydrochloride selective Kca2 SK small channels conductance calcium ca2+ activated potassium K+ modulators inhibits inhibitors Ca2+-Activated Potassium Channels 4597,

extended description :

Selective negative modulator of KCa2 (SK) channels; inhibits SK currents

chemical name text :

N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride

formula :

C 17 H 17 N 3 .HCl

cas num :

875755-24-1

2020 USD :

203

2021 USD :

212 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage